Water → HCID 178433623, compound

Participants

Reaction Conditions

Reaction Steps

(i-1) 15 g of Compound (IV) [R2 =H, R3 =CN], 35 ml of water, and 9.7 ml of triethylamine were mixed and stirred at 50° C. in a warm bath to obtain a brown solution. After heating for about 5 hours, the reacted solution was allowed to stand at room temperature over night. Precipitations of brown crystals was confirmed. The solution was acidified by adding acetic acid. Deposited crystals were collected and recrystallized in dimethylformamide to obtain 13.5 g of 3-cyano-6-(2-hydroxyethyl)-5-methylpyrazolo[1,5-a]pyrimidine-7(4H)-one [R2 =H, R3 =CN in formula (V)] as slight brown crystals having a decomposition temperature of 283° C. at a yield of 90.0%.

Provenance & Evidence