1H-1,2,4-Triazole → HCID 18986638, compound

Participants

Reaction Steps

To a solution of 2-(2,4-difluorophenyl)-2-[1-(1H-1,2,4-triazol-1-yl)ethyl]oxirane (0.5 g, 1.9 m.Mole) in dimethylformamide (20 ml) was added 1,2,4-triazole (0.27 g, 3.8 m.Mole) and anhydrous potassium carbonate (0.27 g, 1.9 m.Mole). Heating, with stirring, was carried out for three hours at 85°. The solvent was evaporated, water (100 ml.) was added and the mixture was then extracted with methylene chloride (3×30 ml). The combined organic extracts were washed with water (3×20 ml), dried over anhydrous magnesium sulphate, and evaporated to an impure solid, weight 0.6 g.

Provenance & Evidence