Hydrochloric Acid → HCID 178490798, compound

Participants

Reaction Steps

A solution of 10.74 g (.029 mole) of N-(3-bromo4-methoxybenzyl)aminoacetaldehyde diethyl acetal hydrochloride and 3.37 g (0.35 mole) of KSCN in 50 ml of H20, 50 ml of ethanol and 5 ml of 3N HCl was refluxed for 4.5 hours. One hundred ml of H2O was added and the mixture was cooled. A solid was filtered, washed with H2O and dried. Recrystallization from ethanol gave 1-(3-bromo-4-methoxybenzyl)-2-mercaptoimidazole, 6.3 g (72%), mp 188°.

Provenance & Evidence