O-Methyltyramine → HCID 131716192, compound

Participants

Reaction Steps

Boc-Asp(OBzl)-OH (38.8 g; 0.12 Mole) was dissolved in CH2Cl2 (250 ml) and cooled in a dry ice/acetone bath. DCC (24.75 g: 0.12 Mole) dissolved in CH2Cl2 (50 ml) was added slowly. After stirring for 10 minutes 4-methoxyphenylethyl amine(15.1 g; 0.1 Mole) was added dropwise and stirring was continued for another hour at room temperature. The mixture was filtered and the filtrate was washed with saturated NaHCO3 solution (3 x 50 ml) and 1N HCl (50 ml). The organic phase was dried over sodium sulfate and evaporated to an oil. Yield: 41.5 g; FAB-MS: (M+Li)=463.

Provenance & Evidence