HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → Ethyl 3-(chlorocarbonyl)pyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 14989183 | HCID 14989183 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 3-(chlorocarbonyl)pyrrolidine-1-carboxylate | HCID 14989184 | 100% |
Reaction Steps
To a stirred solution of 44 parts of 1-(ethoxycarbonyl)-3-pyrrolidinecarboxylic acid in 520 parts of dichloromethane were added dropwise 35.7 parts of thionyl chloride at 20° C. Upon complete addition, stirring was continued overnight and the reaction mixture was evaporated, yielding 49 parts (100%) of ethyl 3-(chlorocarbonyl)-1-pyrrolidinecarboxylate as an oily residue (int. 25).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04992433 |
| Source dataset | uspto-grants-1991_02 |
| ORD ID | ord-785b818c212d404b9dd8881538f3b4ca |
| Source note | uspto-grants-1991_02 |