Toluene → HCID 20070564, compound

Participants

Reaction Conditions

Reaction Steps

250 ml of toluene and 99 g (0.55 mol) of sodium methylate solution (30% in methanol) are initially placed in a flask equipped with a thermometer, a stirrer, a dropping funnel and a distillation bridge with receiver, and 108.4 g of a methanol/toluene mixture are distilled off until the reaction temperature reaches 109° C. 60 g (0.6 mol) of pinacolone are then added dropwise at the same temperature and 95 g (0.5 mol) of methyl n-hexylthioacetate are added dropwise in the course of 20 minutes. In the course of this a further 32.5 g of a methanol/toluene mixture are distilled off. The mixture is then stirred for a further 35 minutes at 106° C. and is worked up analogously to Example 18. The residue is concentrated and then fractionated in vacuo.

Provenance & Evidence