Potassium Hydroxide → HCID 14849578, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1.00 g of 2'-deoxy-5-fluoro-5'-O-trityluridine in 30 ml cf dioxane were added 0.35 g of finely divided powder of potassium hydroxide and 0.29 g of furfuryl chloride, and the mixture was stirred at 80° C. for 2 hours. The solvent was evaporated off and the residue was dissolved in 30 ml of ethyl acetate The solution was washed with water, dried and concentrated. The residue was dissolved in 15 ml of 80% acetic acid and the solution was left to stand at 80° C. for 2 hours The solvent was evaporated off and the residue was dissolved in 30 ml of ethyl acetate, and the solution was washed with water, dried and concentrated. The residue was treated with chloroform and the insoluble matters were filtered and recrystallized from ethanol, thereby giving 0.37 g of 2'- deoxy-5 fluoro-3'-O-furfuryluridine.

Provenance & Evidence