HCID 14849623, compound → HCID 18643717, compound

HRID 981728Notes

Reaction equation

HRID 981728 reaction equation
C(OC([NH:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][C@H:15]1[O:19][C@@H:18]([N:20]2[CH:27]=[C:26]([F:28])[C:24](=[O:25])[NH:23][C:21]2=[O:22])[CH2:17][C@@H:16]1[O:29][CH2:30][C:31]1[S:35][C:34]([Cl:36])=[CH:33][CH:32]=1)=[O:12])=O)(C)(C)C>Cl.O1CCOCC1>[ClH:36].[NH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][C@H:15]1[O:19][C@@H:18]([N:20]2[CH:27]=[C:26]([F:28])[C:24](=[O:25])[NH:23][C:21]2=[O:22])[CH2:17][C@@H:16]1[O:29][CH2:30][C:31]1[S:35][C:34]([Cl:36])=[CH:33][CH:32]=1)=[O:12]

Participants

3

Reactant 1

HCID 14849623HCID 14849623, compound

Product 1

HCID 18643717HCID 18643717, compound

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

To 0.82 g of 5'-O-[N-(t-butoxycarbonyl)-β-alanyl]3'-O-(5-chloro-2-thenyl)-2'-deoxy-5-fluorouridine obtained in Example 7 was added 10 ml of 4N hydrochloric acid-dioxane, and the mixture was stirred at room temperature for 30 minutes.

Sources & evidence

ORD record
ord-2400dc3680d644c99908e767be4ee65c
Source dataset
uspto-grants-1991_02
Patent number
US04992534

Reaction notes

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