HCID 14849635, compound → HCID 14849651, compound

Participants

Reaction Steps

To a solution of 1.10 g of 5'-O-(O-benzyl-N- benzyloxycarbonyl-L-tyrosyl)-2'-deoxy-5-fluoro-3'-O-furfuryluridine prepared in Example 14 in 50 ml of methanol was added 0.11 g of 5% palladium-carbon, and the mixture was stirred in a hydrogen stream under ambient temperature and pressure condition for 2 hours. The catalyst was filtered off, and the solvent was evaporated off under reduced pressure. The residue was placed on silica gel column and eluted with 5% methanol-chloroform for purification, thereby giving 0.13 g of 2'-deoxy-5- fluoro-3'-O-furfuryl-5'-O-L-tyrosyluridine.

Provenance & Evidence