HCID 14849659, compound → HCID 18643714, compound

HRID 981731Notes

Reaction equation

HRID 981731 reaction equation
C(OC([N:8]1[CH2:38][CH2:37][CH2:36][C@H:9]1[C:10]([O:12][CH2:13][C@H:14]1[O:18][C@@H:17]([N:19]2[CH:26]=[C:25]([F:27])[C:23](=[O:24])[NH:22][C:20]2=[O:21])[CH2:16][C@@H:15]1[O:28][CH2:29][C:30]1[S:34][C:33]([Cl:35])=[CH:32][CH:31]=1)=[O:11])=O)(C)(C)C>Cl.O1CCOCC1>[ClH:35].[Cl:35][C:33]1[S:34][C:30]([CH2:29][O:28][C@@H:15]2[C@@H:14]([CH2:13][O:12][C:10](=[O:11])[C@@H:9]3[CH2:36][CH2:37][CH2:38][NH:8]3)[O:18][C@@H:17]([N:19]3[CH:26]=[C:25]([F:27])[C:23](=[O:24])[NH:22][C:20]3=[O:21])[CH2:16]2)=[CH:31][CH:32]=1

Participants

3

Reactant 1

HCID 14849659HCID 14849659, compound

Product 1

HCID 18643714HCID 18643714, compound

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

To 1.21 g of 5'-O-[N-(t-butoxycarbonyl)-L- prolyl]-3'-O-(5-chloro-2-thenyl)-2'-deoxy-5-fluorouridine prepared in Example 27 was added 20 ml of 4N hydrochloric acid-dioxane, and the mixture was stirred at room temperature for 30 minutes.

Sources & evidence

ORD record
ord-149705e5daec42fca3c6df6e7c1ebc62
Source dataset
uspto-grants-1991_02
Patent number
US04992534

Reaction notes

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