反应详情

温度

130 °C

29.43 g (0.15 mol) of 2-(4-fluorophenyl)-3,3-dimethyl-2-methoxyoxirane and 52.3 g (0.60 mol) of morpholine are brought together, and the mixture is heated to reflux temperature (about 130° C.). After 23 hours the excess morpholine is distilled off. The residue is taken up with toluene, and the mixture is extracted with dilute hydrochloric acid. The hydrochloric acid solution is rendered alkaline and is extracted with toluene. The toluene solution is dried with K2CO3 and is concentrated. The residue, 34.0 g, crystallises out from ethyl acetate with a melting point of 63°-66° C.

1. temperaturethe mixture is heated
2. distillationAfter 23 hours the excess morpholine is distilled off
3. extractionthe mixture is extracted with dilute hydrochloric acid
4. extractionis extracted with toluene
5. dry with materialThe toluene solution is dried with K2CO3
6. concentrationis concentrated
7. customThe residue, 34.0 g, crystallises out from ethyl acetate with a melting point of 63°-66° C.