HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 981750Generated: October 31, 2026
Morpholine → 2-Methyl-1-(4-morpholinophenyl)-2-morpholinopropan-1-one
https://huagongshe.com/reaction/981750
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(4-Fluorphenyl)-2-methyl-2-morpholino-1-propanone | HCID 15405305 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-Methyl-1-(4-morpholinophenyl)-2-morpholinopropan-1-one | HCID 19879493 | — |
Reaction Steps
15.08 g (0.06 mol) of 1-(4-fluorophenyl)-2-methyl-2-morpholinopropan-1-one and 5.23 g (0,06 mol) of morpholine are dissolved in 25 ml of dimethyl sulfoxide, and the solution is heated to 160° C. together with 8.3 g (0.06 mol) of potassium carbonate. After 18 hours of stirring at about 160° C. the suspension is cooled down and is poured onto an ice-water mixture. The crystals are filtered off, are washed with water and are recrystallised from ethanol. Melting point 114°-116° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04992547 |
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| Source dataset | uspto-grants-1991_02 |
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| ORD ID | ord-32e12934db114f72b1eac1e5ede315b3 |
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| Source note | uspto-grants-1991_02 |
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