HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 981752Generated: October 30, 2026
Potassium Carbonate → 2-Methyl-1-[4-(4-methylpiperazino)phenyl]-2-(4-methylpiperazino)-propan-1-one
https://huagongshe.com/reaction/981752
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 1-(4-Fluorophenyl)-2-methyl-2-(4-methylpiperazino)-propan-1-one | HCID 19879482 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-Methyl-1-[4-(4-methylpiperazino)phenyl]-2-(4-methylpiperazino)-propan-1-one | HCID 19879431 | — |
Reaction Steps
13.2 g (0.05 mol) of 1-(4-fluorophenyl)-2-methyl-2-(4-methylpiperazino)-propan-1-one and 6.5 g (0.065 mol) of 1-methylpiperazine are dissolved in 20 ml of dimethyl sulfoxide, and the solution is heated to about 115° C. together with 6.9 g (0.05 mol) of potassium carbonate. After 15 hours of stirring at about 115° C. the suspension is cooled down and is poured at about 60° C. onto ice. The crystals are filtered off and are recrystallised twice from ethyl acetate. Melting point 133°-136° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04992547 |
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| Source dataset | uspto-grants-1991_02 |
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| ORD ID | ord-0f21081b62ee42098af4acd170405558 |
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| Source note | uspto-grants-1991_02 |
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