L-Malic Acid → HCID 14988496, compound

HRID 981760Notes

Reaction equation

HRID 981760 reaction equation
[C:1]([OH:9])(=[O:8])[C@H:2]([CH2:4][C:5]([OH:7])=[O:6])[OH:3].F[C:11](F)(F)[C:12](O)=O.C1(=O)OC(=O)C[C@@H]1O>C(O)C>[CH2:11]([O:8][C:1](=[O:9])[C@H:2]([CH2:4][C:5]([OH:7])=[O:6])[OH:3])[CH3:12]

Participants

4

Reactant 2

HCID 222656L-Malic AcidHCID 131716795HCID 131716795, compound

Product 1

HCID 14988496HCID 14988496, compoundYield 98.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

By using the reagents, procedures and conditions described by Example 3A L-malic acid was converted to L-malic anhydride trifluoroacetate and the latter was allowed to react with ethyl alcohol to provide in 98.7% yield L-malic acid monoethyl ester melting at about 48° to about 49.5° C.

Sources & evidence

ORD record
ord-9a08ea084af546f385e19ea3e36dcd06
Source dataset
uspto-grants-1991_02
Patent number
US04992544

Reaction notes

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