P-Phenylenediamine → HCID 13628653, compound

Participants

Reaction Steps

132.85 g of 2-chloro-5-nitrophenyl hydroxyethyl sulfone are added at 65° C. under nitrogen to a solution of 118.8 g of 1,4-phenylenediamine in 500 ml of methanol in the course of 30 minutes. The reaction solution is stirred at this temperature for a further 4 hours and is then allowed to cool down to room temperature, and the reaction product is crystallized by addition of 1 l of ice-water. Filtering with suction and drying gives 168 g of 2-(4-aminophenylamino)-5-nitrophenyl hydroxyethyl sulfone having a melting point of 147°-149° C. and a purity of >99%, which corresponds to a yield of 99% of theory, relative to starting 2-chloro-5-nitrophenyl hydroxyethyl sulfone.

Provenance & Evidence