Ammonia → HCID 20071066, compound

HRID 981815Notes

Reaction equation

HRID 981815 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([NH:9][CH3:10])[C:3]=1[N+:11]([O-:13])=[O:12].[NH3:14]>O.C(O)C>[Cl:8][C:6]1[CH:5]=[C:4]([NH:9][CH3:10])[C:3]([N+:11]([O-:13])=[O:12])=[C:2]([NH2:14])[CH:7]=1

Participants

5

Reactant 2

HCID 222AmmoniaHCID 20071071HCID 20071071, compound

Product 1

HCID 20071066HCID 20071066, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

0.034 mole (7.5 g) of 2,4-dichloro-6-methylaminonitrobenzene is added in an autoclave to 100 ml of a 28% strength solution of ammonia in water and 50 ml of ethanol. The reaction mixture is heated to 145°-150° C. for 12 hours, the pressure being 12 kg/cm2. After cooling, the expected product precipitates from the reaction mixture. After being filtered off and reslurried in water, it is dried hot under vacuum in the presence of phosphorus pentoxide. Recrystallized from isopropanol, it melts at 129° C.

Workup

  1. temperatureThe reaction mixture is heated to 145°-150° C. for 12 hours
  2. temperatureAfter cooling
  3. customthe expected product precipitates from the reaction mixture
  4. filtrationAfter being filtered off
  5. dry with materialit is dried hot under vacuum in the presence of phosphorus pentoxide
  6. customRecrystallized from isopropanol, it melts at 129° C.

Sources & evidence

ORD record
ord-83c131031f14438284faf397fa7f4eb6
Source dataset
uspto-grants-1991_02
Patent number
US04992586

Reaction notes

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