Ammonia → HCID 20068400, compound

Participants

Reaction Steps

A mixture of 25 parts of 1-(1,2,3,4-tetrahydro-2,2-dimethyl-1-naphthalenyl)-1H-imidazole-5-carbonitrile and 360 parts of methanol, saturated with ammonia was hydrogenated at normal pressure and at room temperature with 2 parts of Raney nickel catalyst. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was dried at 100° C., yielding 23 parts (90.0%) of 1-(1,2,3,4-tetrahydro-2,2-dimethyl-1-naphthalenyl)-1H-imidazole-5-methanamine as an oily residue (compound 2.37).

Provenance & Evidence