Nitric Acid → HCID 20068746, compound

Participants

Reaction Steps

A solution of 100 mg (0.39 mmol) of Compound 1 obtained in Example 1 in 0.13 ml of sulfuric acid was added dropwise to an acid mixture consisting of 0.045 ml of 61% nitric acid and 0.35 ml of 96% sulfuric acid with ice cooling, followed by stirring for 30 minutes. After neutralization with an aqueous 50% sodium hydroxide, the mixture was extracted with chloroform. The organic layer was washed with brine, dried over anhydrous sodium sulfate and filtered. The solvent was evaporated under reduced pressure. The obtained crude product was purified by silica gel column chromatography (eluting solvent: chloroform/methanol=10/1) to afford 13 mg of Compound 14.

Provenance & Evidence