2-(1H-Indol-5-yl)-N,N-dimethylethenesulphonamide → N,N-Dimethyl-1H-indole-5-ethanesulphonamide

Participants

Reaction Steps

A solution of the product of Stage (i) (3.8 g) in ethanol (400 ml) was hydrogenated at room temperature and pressure over 10% palladium oxide on charcoal (50% aq. paste, 0.5 g), for 2 h. The catalyst was filtered off and replaced with a fresh batch (50% aq. paste, 0.5 g) and hydrogenation continued for a further 1 h. The catalyst was filtered off and the filtrate evaporated in vacuo to give a solid (2.8 g) which was recrystallised from a mixture of ethyl acetate and hexane to give the title compound as a solid (2.0 g) m.p. 125°-127°.

Provenance & Evidence