Methanol → HCID 70073965, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 0.50 g (2.04 mmol) of dl-β-(4-Thiazolyl)alanine dihydrochloride (dl connotes a 50/50 mixture of dextrorotatory and levorotatory isomers) in 9 ml of methanol was cooled to 0° C. and treated with 0.21 ml (2.86 mmol) of thionyl chloride. The resulting solution was heated at 55° C. for 16 h. Removal of the solvent in vacuo gave 0.56 g (99%) of the desired compound as a white solid. Mass spectrum: (M+H)+ =187.

Provenance & Evidence