HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Nppb
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Phenylpropylamine | HCID 16259 | — |
| Reactant | 2-Chloro-5-nitrobenzoic acid | HCID 17287 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | Nppb | HCID 4549 | — |
Reaction Steps
A solution of 15.3 g of 2-chloro-5-nitrobenzoic acid and 49 g of 3-phenylpropylamine in 60 ml of dimethylacetamide is heated at 145° C. for 2 hours. After cooling, 300 ml of water are added, and the mixture is acidified (pH 2 to 1) with 2 N HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04994493 |
| Source dataset | uspto-grants-1991_02 |
| ORD ID | ord-b4dbf659a3694623bb7dda461ecb6be5 |
| Source note | uspto-grants-1991_02 |