Boron trifluoride etherate → HCID 20069137, compound

Participants

Reaction Conditions

Reaction Steps

3.4 ml of boron trifluoride etherate are added to a solution of 5.6 g of methyl 2-(3-phenylpropanoylamino)benzoate in 35 ml of anhydrous 1,2-dimethoxyethane. After cooling to 0° C., 3.4 g of sodium borohydride are added in portions, while stirring and cooling, and then the mixture is stirred at 60° C. for 45 hours and, after cooling, is poured onto ice-water. Extraction with ethyl acetate, evaporation off of the solvent and column chromatography of the residue as described under (a) provides methyl 2-(3-phenylpropylamino)benzoate.

Provenance & Evidence