Sodium Hydroxide → HCID 67793081, compound

Participants

Reaction Steps

A mixture of methyl 3,4,5-triphenyl-lH-pyrazol-1-nonanoate (3.45 g, 7.4 mmol), 5 N sodium hydroxide solution (4.44 mL, 22 mmol) and methanol (60 mL) was heated at reflux for 1 hour. The solvent was evaporated, the residue diluted with water and 2 N hydrochloric acid solution added until pH =1. A yellow solid was filtered off and recrystallized from dichloromethane/hexane to afford 3,4,5-triphenyl-lH-pyrazol-1-nonanoic acid hydrate (3 g, 89%); m.p. =110°-112° C. MS(CI): m/e =453 (MH+).

Provenance & Evidence