Potassium Iodide → HCID 15725742, compound

Participants

Reaction Steps

A mixture of 1-(6-bromohexyl)-3,4,5-triphenyl-lH-pyrazole (6.53 g, 14 mmol), methyl mercaptoacetate (1.66 g, 15 mmol), potassium carbonate (2.26 g, 16.5 mmol), potassium iodide (catalytic amount) and acetonitrile (150 mL) was heated at reflux for 4 hours. The mixture was cooled, filtered and concentrated in vacuo to give an oil. Chromatography on a column of silica gel using a mixture of hexane and ethyl acetate (4:1) as eluent furnished methyl [[6-(3,4,5-triphenyl-lH-pyrazol-1-yl)hexyl]thio]acetate (6.47 g, 91%) as an oil.

Provenance & Evidence