Methanol → HCID 19982294, compound

Participants

Reaction Conditions

Reaction Steps

Oxone was bubbled through a solution of 3,4,5-triphenyl-lH-pyrazole-1-undecene (6.78 g, 15 mmol) in dichloromethane (175 mL) and methanol (0.73 g, 22 mmol) maintained at -78° C. for 1.5 hours. The ozone supply was removed, dimethylsulfide (30 mL) added and the mixture allowed to warm to room temperature over 2 hours. The solution was dried over sodium sulfate, concentrated in vacuo and the residue chromatographed on a column of silica gel. Elution with a mixture of hexane and ethyl acetate (9:1) gave 3,4,5-triphenyl-lH-pyrazole-1-decanal (2.93 g, 43%) as an oil. MS(CI): m/e =451 (MH+).

Provenance & Evidence