Hydrochloric Acid → HCID 57249218, compound

Participants

Reaction Steps

A solution of 135 mg (0.4 mmol) of [1R,3S] 3,4-dihydro-5-methoxymethoxy-1-nitromethyl-3-phenyl-1H-2-benzopyran, from Step 1, in 5 mL of methanol was saturated with anhydrous hydrogen chloride. The resultant mixture was stirred at reflux temperature for 2 h and then concentrated in vacuo. The residue was purified on silica gel eluted with 5% methanol in methylene chloride to afford 75 mg (66% yield) of the title compound.

Provenance & Evidence