Boron tribromide → HCID 67931386, compound

HRID 982119Notes

Reaction equation

HRID 982119 reaction equation
[NH2:1][CH2:2][C@H:3]1[C:8]2[C:9]([CH3:15])=[CH:10][CH:11]=[C:12]([O:13]C)[C:7]=2[CH2:6][C@@H:5]([CH2:16][NH2:17])[O:4]1.B(Br)(Br)[Br:19]>>[BrH:19].[BrH:19].[NH2:1][CH2:2][C@H:3]1[C:8]2[C:9]([CH3:15])=[CH:10][CH:11]=[C:12]([OH:13])[C:7]=2[CH2:6][C@@H:5]([CH2:16][NH2:17])[O:4]1

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 86744626HCID 86744626, compound

Product 1

HCID 67931386HCID 67931386, compound

Procedure

[1R,3S] 1,3-Bis(aminomethyl)-3,4-dihydro-5-methoxy-1H-2-benzopyran from Step 6 is treated with an excess of boron tribromide as described in Step 6 of Example 145 to give the title compound.

Sources & evidence

ORD record
ord-75a482bc265149f1a09c86a95097f913
Source dataset
uspto-grants-1991_02
Patent number
US04994486

Reaction notes

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