Aluminium lithium hydride → HCID 86744627, compound

Participants

Reaction Steps

Lithium aluminum hydride (1.1 mL of a 1.0M solution in diethyl ether, 1.1 mmol) is added dropwise to a solution of 289 mg (1.1 mmol) of [1R,3S] 1-azidomethyl-3,4-dihydro-3-hydroxymethyl-5-methoxy-8-methyl-1H-2-benzopyran, the product of Step 4 of Example 142, in 10 mL of anhydrous diethyl ether at 0° C. The reaction mixture is allowed to warm to ambient temperature and stirred for 40 min. The reaction mixture is cooled to 0° C. and quenched by the sequential addition of 42 μL of water, 42 μL of 15% aqueous sodium hydroxide solution and 126 μL of water. The solution is dried over anhydrous magnesium sulfate and filtered. The filtrate is concentrated in vacuo to give the title compound.

Provenance & Evidence