反应详情

Sodium borohydride (6.8 g) is added to a suspension of 6.1 g (23.3 mmol) of 1-cyano-5-methoxy-3-phenyl-3,4-dihydronaphthalene, from Step 1, in 100 mL of absolute ethanol and the reaction mixture is heated at reflux temperature for 1.5 h. The solvent is evaporated under reduced pressure and the residue partitioned between equal volumes of ethyl acetate and 1N aqueous hydrochloric acid solution. The layers are separated and the organic layer is washed with aqueous sodium bicarbonate solution and brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give the title compound.

1. temperaturethe reaction mixture is heated
2. temperatureat reflux temperature for 1.5 h
3. customThe solvent is evaporated under reduced pressure
4. customthe residue partitioned between equal volumes of ethyl acetate and 1N aqueous hydrochloric acid solution
5. customThe layers are separated
6. washthe organic layer is washed with aqueous sodium bicarbonate solution and brine
7. dry with materialdried over anhydrous magnesium sulfate
8. filtrationfiltered
9. concentrationconcentrated