Proton sponge → HCID 20069038, compound

Participants

Reaction Steps

To a solution of 0.89 g (2.52 mmol) of 2-benzyl-6-methoxy-4-phenyl-2,3,4,5-tetrahydrobenzo[e]isoindole, from Step 6, in 22 mL of 1,2-dichloroethane is added 0.11 g (0.05 mmol) of 1,8-bis(dimethylamino)-naphthalene and 0.33 mL (3.15 mmol) of 1-chloroethylchloroformate at 0° C. The solution is heated to reflux for 2 h and the solvent removed in vacuo. The residue is filtered through silica gel, eluting with 25% ethyl acetate in hexanes. After concentration under reduced pressure, methanol (20 mL) is added and the solution is heated to reflux for 30 minutes, before the solvent is removed in vacuo to give the title compound.

Provenance & Evidence