HCID 53778256, compound → HCID 178507596, compound

Participants

Reaction Steps

Iron powder (3.5 g) was added in portions over five minutes to a slurry of 1-(2,3,4,5,6-pentachlorophenyl)-3-(2'-chloro-5'-nitroanilino)-2-pyrazoline-5-one (5 g) in trifluoroacetic acid (50 ml) at 70° C. The yellow color of the nitropyrazolone rapidly disappeared, and after stirring at 70°-75° C. for ten minutes the hot solution was separated from any unreacted iron and added to stirred ice-water (400 ml). The resultant off-white precipitate of the aminopyrazolone was filtered off, washed with water and dried. The yield was 4.6 g (98%); single spot by thin layer chromatography.

Provenance & Evidence