反应详情

A solution of 4.6 g of 2-chloroimidazo[1,2-a]pyridine- 3-sulfonyl chloride in 60 ml of acetonitrile is added to 60 ml of aqueous ammonia under cooling and the mixture is stirred at room temperature for 2 hours. The acetonitrile is distilled off under reduced pressure and the resulting crystals are collected by filtration and washed with water to give 3.8 g of the title compound. Recrystallization from dilute ethanol gives colorless needles.

1. temperatureunder cooling
2. distillationThe acetonitrile is distilled off under reduced pressure
3. filtrationthe resulting crystals are collected by filtration
4. washwashed with water