HCID 57137252, compound → HCID 57044005, compound

Participants

Reaction Conditions

Reaction Steps

In a 100 ml-volume egg plant type flask equipped with a three-way cock whose atmosphere had been displaced with nitrogen was charged 15 mg (0.009 mmole) of Ru2Cl4 ((R)-BINAP)2 (NEt3), and 500 mg (1.75 mmole) of t-butyl (5S)-6-t-butoxy-5-hydroxy-3-oxohexanoate as synthesized in Example 4 and 60 ml of methanol were added thereto to form a solution. The solution was transferred to a 100 ml-volume autoclave whose atmosphere had been displaced with nitrogen and stirred at 30° C. for 16 hours under a hydrogen pressure of 50 kg/cm2 to conduct hydrogenation. The solvent was removed by distillation, and the residue was purified by silica gel column chromatography to obtain 340 mg (yield: 68%) of t-butyl (3R,5S)-6-t-butoxy-3,5-dihydroxyhexanoate.

Provenance & Evidence