Sodium Hydroxide → 2-Amino-4,5-difluorobenzoic acid

Participants

Role	Name	HCID	Charge
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	Sodium Formate	HCID 2723810	—
Reactant	4,5-Difluoro-2-nitrobenzoic acid	HCID 4219630	—
Catalyst	Palladium	HCID 23938	—
Solvent	Water	HCID 962	—
Product	2-Amino-4,5-difluorobenzoic acid	HCID 735965	93%

Reaction Conditions

Temperature	90 °C

Reaction Steps

2-nitro-4,5-difluorobenzoic acid (1.0 g) was added to 10 mL of water. 0.2 g of NaOH was added, followed by 1.0 g of sodium formate. 0.05 g of 10% palladium on carbon was added, and the mixture was heated to 90° C. for 2.5 h. After cooling, a suitable internal standard was added. 19F NMR internal standard analysis of the entire reaction mixture indicated a 93% yield of 4,5-difluoroanthranilic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04994606
Source dataset	uspto-grants-1991_02
ORD ID	ord-6fcea16c66834bd38bddcf85ae77586f
Source note	uspto-grants-1991_02