3,4-Dichlorophenyl isocyanate → HCID 14650637, compound

Participants

Reaction Steps

3,4-Dichlorophenyl isocyanate (1.15 g) is added at a temperature in the region of 20° C. to a solution, maintained under an argon atmosphere, of (4RS, 5RS)-2,4-diphenyl-5,6-dihydro-4H-1,3-oxazin-5-ol (1.52 g) in 1,2-dichloroethane (20 cc). The solution obtained is heated to reflux for 6 hours and then concentrated to dryness under reduced pressure (2.7 kPa). After recrystallization in acetonitrile, (4RS, 5RS)-5-(3,4-dichlorophenylcarbamoyloxy)-2,4-diphenyl-5,6-dihydro-4H-1,3-oxazine (2 g), m.p. 184° C., is obtained.

Provenance & Evidence