4-Chlorophenyl Isocyanate → HCID 14650645, compound

Participants

Reaction Steps

4-Chlorophenyl isocyanate (1 g) is added at a temperature in the region of 20° C. to a solution, maintained under an argon atmosphere, of (4RS, 5RS)-2,4-diphenyl-5,6-dihydro-4H-1,3-oxazin-5-ol (1.2 g) in 1,2-dichloroethane (20 cc). The solution obtained is heated to reflux for 7 hours 30 minutes and then concentrated to dryness under reduced pressure (2.7 kPa). After two successive recrystallizations in acetonitrile, (4RS, 5RS)-5-(4-chlorophenylcarbamoyloxy)-2,4-diphenyl-5,6-dihydro-4H-1,3-oxazine (1.1 g), m.p. 200° C., is obtained.

Provenance & Evidence