Phenyl isocyanate → HCID 14650651, compound

Participants

Reaction Steps

Phenyl isocyanate (2.3 g) is added at a temperature in the region of 20° C. to a solution, maintained under an argon atmosphere, of (4RS, 5RS)-2-(2-indolyl)-4-phenyl-5,6-dihydro-4H-1,3-oxazin-5-ol (5.15 g) in 1,2-dichloroethane (50 cc). The solution obtained is stirred for 7 hours under reflux and then concentrated to dryness under reduced pressure (2.7 kPa) at 40° C. After two successive recrystallizations in diisopropyl ether, (4RS, 5RS)-2-(2-indolyl)-4-phenyl-5-phenylcarbamoyloxy-5,6-dihydro-4H-1,3-oxazine (4 g), m.p. 166° C., is obtained.

Provenance & Evidence