1,3-Benzodioxole-5-carboxylic acid → Diisopropyl Ether

Participants

Reaction Steps

N-[(1RS, 2RS)-2,3-Dihydroxy-1-phenylpropyl]-3,4-methylenedioxybenzamide may be prepared in the following manner: working as in Example 8 for the preparation of N-[(1RS, 2RS)-2,3-dihydroxy-1-phenylpropyl]-2-indolecarboxamide but starting with piperonylic acid (4.6 g), oxalyl dichloride (2.6 cc), (2RS, 3RS)-3-amino-3-phenyl-1,2-propanediol (4.17 g) and triethylamine (10.5 cc), and after the precipitate is washed with distilled water and then with diisopropyl ether, N-[(1RS, 2RS)-2,3-dihydroxy-1-phenylpropyl]-3,4-methylenedioxybenzamide (6 g), m.p. 172° C., is obtained.

Provenance & Evidence