Sodium Chloride → HCID 11171063, compound

Participants

Reaction Conditions

Reaction Steps

N-[(2RS, 3RS)-2,3-epoxy-3-phenylpropyl]-trifluoroacetamide (4.9 g) is added to 3.57 N aqueous potassium hydroxide solution (6 cc). After 7 minutes' stirring at a temperature in the region of 20° C., the solution obtained is saturated with sodium chloride and then extracted with dichloromethane (2×50 cc). The organic phases are combined, dried over magnesium sulphate and then filtered, thereby forming a methylene chloride solution of (2RS, 3RS)-2,3-epoxy-3-phenylpropanamine (solution B).

Provenance & Evidence