Sodium Chloride → HCID 11171063, compound

HRID 982270Notes

Reaction equation

HRID 982270 reaction equation
[O:1]1[CH:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:2]1[CH2:3][NH:4]C(=O)C(F)(F)F.[OH-].[K+].[Cl-].[Na+]>>[O:1]1[CH:11]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:2]1[CH2:3][NH2:4]

Participants

4

Reactant 3

HCID 5234Sodium ChlorideHCID 14797Potassium HydroxideHCID 14650569HCID 14650569, compound

Product 1

HCID 11171063HCID 11171063, compound

Conditions

Temperature
20 °C

Procedure

N-[(2RS, 3RS)-2,3-Epoxy-3-phenylpropyl]trifluoroacetamide (11 g) is added to 3.6 N aqueous potassium hydroxide solution (12.5 cc). After 7 minutes' stirring at a temperature in the region of 20° C., the solution obtained is saturated with sodium chloride and then extracted with dichloromethane (2×100 cc). The organic phases are combined, dried over magnesium sulphate and then filtered, thereby forming a methylene chloride solution of (2RS, 3RS)-2,3-epoxy-3-phenylpropanamine (solution B).

Workup

  1. customthe solution obtained
  2. extractionextracted with dichloromethane (2×100 cc)
  3. dry with materialdried over magnesium sulphate
  4. filtrationfiltered

Sources & evidence

ORD record
ord-555a1d179397486884ec073a2417bfa7
Source dataset
uspto-grants-1991_02
Patent number
US04994569

Reaction notes

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