Phenyl isocyanate → HCID 67928889, compound

Participants

Reaction Conditions

Reaction Steps

Phenyl isocyanate (0.95 g) is added at a temperature in the region of 20° C. to a solution, maintained under an argon atmosphere, of (5RS, 6SR)-2-(4-acetylphenyl)-6-phenyl-5,6-dihydro-4H-1,3-oxazin-5-ol (2 g) in tetrahydrofuran (25 cc). The solution obtained is heated to 50° C. for 5 hours and then concentrated to dryness under reduced pressure (2.7 kPa). After recrystallization in ethanol, (5RS, 6SR)-2-(4-acetylphenyl)-6-phenyl-5-phenylcarbamoyloxy-5,6-dihydro-4H-1,3-oxazine (1.9 g), m.p. 168° C., is obtained.

Provenance & Evidence