Phenyl isocyanate → HCID 67929863, compound

Participants

Reaction Steps

By working in a manner similar to that described in Example 38, but starting with (5RS, 6SR)-2-(4-morpholinophenyl)-6-phenyl-5,6-dihydro-4H-1,3-oxazin-5-ol (1.1 g) and phenyl isocyanate (0.46 g), and after purification of the crude product obtained by chromatography on silica (0.063-0.2 mm; 60 g) contained in a column 2.5 cm in diameter, eluting in 20-cc fractions with an ethyl acetate/methanol mixture (95:5 by volume), recovery and concentration under reduced pressure (2.7 kPa) of fractions 4 to 8 followed by recrystallization of the residue thereby obtained in an ethyl acetate/isopropyl ether mixture (50:50 by volume), (5RS, 6SR)-2-(4-morpholinophenyl)-6-phenyl-5-phenylcarbamoyloxy-5,6-dihydro-4H-1,3-oxazine (0.55 g), m.p. 175° C., is obtained.

Provenance & Evidence