Phenyl isocyanate → HCID 86744629, compound

Participants

Reaction Steps

A mixture of (5RS, 6SR)-2-[4-(N-methyltrifluoroacetamido)phenyl]-6-phenyl-5,6-dihydro-4H-1,3-oxazin-5-ol (1.54 g) and phenyl isocyanate (0.6 g) in 1,2-dichloroethane (25 cc) is heated to reflux for 18 hours. The reaction mixture is then concentrated to dryness under reduced pressure (2.7 kPa). After recrystallization of the residue thereby obtained in isopropyl ether, (5RS, 6SR)-2-[4-(N-methyltrifluoroacetamido)phenyl]-6-phenyl-5-phenylcarbamoyloxy-5,6-dihydro-4H-1,3-oxazine (0.77 g), m.p. 160° C., is obtained.

Provenance & Evidence