Isopropanol → 5-(Isopropylsulfamoyl)-1,4-dihydro-2.6-dimethyl-4-(3-nitrophenyl)nicotinic acid 2-propoxyethyl ester

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Reaction Steps

A solution of 3.12 g (0.01 mol) of α-acetyl-N-isopropyl-3-nitrostyrenesulfonamide in 30 ml of isopropanol is treated with 1.87 g (0.01 mol) of 3-aminocrotonic acid 2-propoxyethyl ester and 1.16 g (0.005 mol) of DL-camphor-10-sulfonic acid in accordance with the procedure described in Example 1. After chromatography on silica gel with methylene chloride/ethyl acetate (4:1) as the elution agent the crude product is recrystallized from isopropanol. There is obtained 1.0 g (21%) of 5-(isopropylsulfamoyl)-1,4-dihydro-2.6-dimethyl-4-(3 -nitrophenyl)nicotinic acid 2-propoxyethyl ester, m.p. 155°-158°, as a colorless crystalline powder.

Provenance & Evidence