HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → alpha-acetyl-N-isopropyl-3-nitrostyrenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 3-Nitrobenzaldehyde | HCID 7449 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | N-isopropyl-2-oxopropanesulfonamide | HCID 20069376 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | alpha-acetyl-N-isopropyl-3-nitrostyrenesulfonamide | HCID 54206999 | — |
Reaction Steps
A solution of 7.5 g (about 0.04 mol) of N-isopropyl-2- -oxopropanesulfonamide and 6.0 g (0.04 mol) of 3-nitrobenzaldehyde in 40 ml of benzene is treated with 0.16 ml of piperidine and 0.48 ml of glacial acetic acid in an analogous manner to that described in Example 1. The oily crude product is triturated with ether, whereby crystallization occurs. There are obtained 2.5 g of α-acetyl-N- -isopropyl-3-nitrostyrenesulfonamide in the form of colorless crystals, m.p. 153°-157°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04994612 |
| Source dataset | uspto-grants-1991_02 |
| ORD ID | ord-745c4194f74d4d4ab5e4de6da4a63e73 |
| Source note | uspto-grants-1991_02 |