Methyl 3-aminocrotonate → HCID 67946089, compound

Participants

Reaction Steps

A solution of 3.67 g (0.01 mol) of α-(cyclohexyl- carbonyl)-N,N-dimethyl-3 -nitrostyrenesulfonamide in 30 ml of isopropanol is treated with 1.15 g (0.01 mol) of 3-aminocrotonic acid methyl ester and 1.16 g (0.005 mol) of DL-camphor-10-sulfonic acid in accordance with the procedure described in Example 1. After chromatography on silica gel with methylene chloride/ethyl acetate (9:1) as the elution agent the crude product is recrystallized from acetonitrile. There are obtained 1.5 g (32%) of 6-cyclohexyl-5-(dimethylsulfamoyl)-1,4 -dihydro-2-methyl-4-(3-nitrophenyl)nicotinic acid methyl ester, m.p 185°-188°, as a colorless crystalline powder.

Provenance & Evidence