Acetic Anhydride → HCID 20067450, compound

Participants

Reaction Steps

3.4 g of 8-amino-7-chloro-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine in 50 ml of methylene chloride was treated with 4 ml of acetic anhydride followed by addition of 10 mg. of 4-dimethylaminopyridine. The resulting mixture was stirred at room temperature for 2 hours, and the solvent was removed in vacuo. The residue was stirred with a mixture of ether and sodium bicarbonate solution for 1 hour. The ether layer was separated, dried over sodium sulfate and evaporated in vacuo. The resulting crude product of this example (3.1 g) was used in the following step B.

Provenance & Evidence