Triethylamine → HCID 20067657, compound

Participants

Reaction Steps

A solution of 4.75 g. (20 mmol) 2-(benzylaminocarbonylamino)-3-chloropropionitrile and 6 ml. triethylamine in 50 ml. dry tetrahydrofuran is heated to reflux for 5 hours. Subsequently, the precipitate formed is filtered off, the filtrate is evaporated to dryness and the residue is chromatographed on silica gel (elution agent: ethyl acetate) to give 2.5 g. (62.2% of theory) of the title compound; m.p. 139°-141° C.

Provenance & Evidence