Benzylamine → HCID 19876765, compound

Participants

Reaction Steps

A solution of 2-[2-[(6-bromohexyl)oxy]ethyl]benzoxazole (1.55 g) in benzylamine (6 ml) was heated at 125° for 2 h under nitrogen, cooled, diluted with ether (100 ml) and the ether suspension washed with 8% sodium bicarbonate solution (25 ml). The organic phase was dried and evaporated in vacuo. Benzylamine was removed by bulb to bulb distillation (b.p. 130°/25 mm) to leave a product which was purified by chromatography over silica (Merck 60) eluting with System B (89:10:1) to afford the title compound as a red oil (250 mg), t.l.c. (System A 39:10:1) Rf 0.55.

Provenance & Evidence