Acetic Acid → HCID 14651080, compound

Participants

Reaction Conditions

Reaction Steps

To the yellow solution of the dianion was added a 0.25M THF solution of 8.58 g (30 mmoles) of the aldehyde prepared in Step 7. The addition took 30 minutes. The reaction mixture was stirred an additional 30 minutes at -10° C., then quenched with 9.47 (165.6 mmoles) of acetic acid in 40 ml of THF. The reaction mixture was poured into ethyl acetate and extracted with H2O, saturated NaHCO3 and brine.

Provenance & Evidence